With apple you’re limited to 5 sending addresses per domain, so no I cannot reply as the from address to most, but that hasn’t been an issue for me at all.

Depends on your use case. I went with using a custom domain with my iCloud mail account. This lets me accept all messages sent to my custom domain.

So when I create accounts I just use that as the email address like this: [email protected], [email protected], etc.

They all go to one mailbox but that’s all I need anyway. I’ve been happy with it.

Unfortunately having the vaccine isn’t a guarantee that you cannot be infected. Herd immunity can do that, but that requires mostly everyone getting the vaccine.

So, even people that are vaccinated will be affected by people refusing the vaccine.