• I want this so bad, I have lost all cartilage in my wrists and I don’t want to get them fused.

    • I couldn’t imagine how shitty that must be, I really hope this advancement does help you regrow yours so you don’t have to get them fused.

  • 3 hours

    i have femoral head necrosis, though so technically not arthritis but that is absolutely great news for everything else

  • 8 hours

    I would like to order one new left knee cartilage please!

    • 8 hours

      “but does it cause cancer” is the new “but so does a handgun” comic.

    • 6 hours

      I would trade cancer down the road for my joints working now :(

      • Genuinely one of the questions that is coming up more and more in healthcare is trying to figure out what cancer is okay to just live with. As in, the treatment would be more of an impact on quality of life vs letting the cancer develop slower than the person would die of other causes.

        This is especially becoming more of an issue as we get much better at detecting cancer.

  • 12 hours

    I’m glad to hear that stuff like this is still going on. Nice!

    • 8 hours

      in fact, we’re in the early days of human gene technology, hormone therapy, biochemistry tempering etc.

        • The mice need a floatilla and a few celebrities to turn on the red carpet and go “Yeah but what about the genocide of mice? – Chekmate, deuces.”

      • 7 hours

        Uhhh you do know what happens to them at the end of the experiment right?

        • They turn into a soup-like homogenate. As is natural in the life cycle of a lab mouse.

          And if they weren’t euthanized they would almost certainly die of horrible horrible cancerous tumors. Not because of anything the labs do, but because it’s a crime against nature for a mouse to live past maybe 2 years.

    • And human tissues, and it’s been shown to be safe in phase I trials.

      So saying “in mice” undersells where they are at.

      • 8 hours

        Yeah looks like poster either didn’t read the article or just didn’t read it sufficiently but decided to be reactionary anyways.

    • 8 hours

      They started with mice. As does all experiments.

      Did you only read half way through before reaction posting?

      Weird.

      • 8 hours

        it’s weird to comment “weird” on everything

        • 8 hours

          Yes it would be. Good thing that’s not happening. How’s the spread of the misinformation? I see I’m hitting a few nerves.

          GOOD.

  • Wow, this is really exciting. I guess it’ll take years more research before we’ll know if this can benefit humans, but if they can replicate the results with humans then it could potentially prevent chronic pain and mobility issues in millions of people.

    • 9 hours

      Hopefully not just humans. Many dogs for example suffer from the very same issues when they get older.

      • 8 hours

        it’s always seemed weird to me that aging takes 20 years in dogs but 80 years in humans. i mean, if it’s a physical hardware failure, then you would expect it to be independent of age and only dependent on past physical load.

        • 7 hours

          Not a scientist, but from what I know it’s all linked and proportional to a species’ lifespan, so dogs are growing up faster, but also aging faster than humans in general. If a human reaches sexual maturity at 15, a dog does so at 1 or 2.

    • 7 hours

      Take a drug to regrow cartilage and get w vaccine for the cancer it allows.

      With enough science, anything is possible.

      • I wonder if that’ll be the route to immortality from age.

        The drug that stops the aging, and a drug that stops the cancer.

        Trying to solve just the aging never works, but the combo does.

    • … potentially prevent chronic pain and mobility issues in millions of tens of ultrarich people.

      FTFY

  • 19 hours

    Good. Biological aging is nothing more than a series of processes, not an inherent property of atoms, and it’s time we start getting serious about anti-aging and life extension.

    But probably not, seeing what the world is like.

    • Its mostly billionaires who will be able to benefit from life extension… do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?

      • No worries about that, there is no changing the maximum age seemingly, not unless you genetically engineered babies with tech we don’t have yet.

        Everyone is born with stem cells that carry so many copies of cells that are preprogrammed to die after a point to then be replaced by those stem cells. No drug can make more copies after the fact.

        Then of course the dna gets denatured just by radiation and pollution and time.

        Neither of these will or can be solved after someone is born. They can extend the average lifespan of a group, but they can’t exceed the maximum, which has remained constant throughout human history even as the average has changed drastically.

        • 4 hours

          All of those things seem to be related to information processing, not any inherent property of atoms.

          “Then of course the dna gets denatured just by radiation and pollution and time.”

          Pretty sure “dna” isn’t just present in one cell in the body.

          Also, how can two thirty year olds make a zero year old baby?

          • Have you read anything about this before espousing your grand pronouncements here?

            Seriously, like, you are so far in left field here, I can’t even respond.

            • 3 hours

              https://vadim.oversigma.com/MAS862/Project.html

              But lay on MacDuff, pour your great knowledge upon me. Tell me how a carbon atom knows it’s in a thirty year old body or 95 year old?

              “Also, how can two thirty year olds make a zero year old baby?”

              Surely you can respond to this puzzler? Even if I’m in the left field of the Andromeda Galaxy?

              Explain away, professor!

              • If you want to address the scientific points I made, I will respond. Your poetry is neither here nor there, pal.

        • 10 hours

          What’s the maximum? About 120?

          Imagine having 100 or more healthy years. That seems like sci-fi, but may be possible one day still.

          It will also mean working until you’re 100 before the national pension kicks in unfortunately lol

          • Around 120 is maximum yes. I think some french woman might have gotten near 130 but I forget.

            Unless you believe the bible, in which case hundreds and hundreds of years. And woman was made from man’s rib. Makes sense.

      • 18 hours

        Why do you think that? We already benefit from life extension. And why only 300?

        • “I plan to live forever, of course, but barring that I’d settle for a couple thousand years. Even five hundred would be pretty nice.”

          CEO Nwabudike Morgan, “Sid Meier’s Alpha Centauri” (1999)

      • If you’re that worried, start working towards killing them. Seems like it’s going to be necessary step either way to correct many problems in the world. What’s one more reason for the pyre?

      • 4 hours

        And we’ve achieved some of it, or are you telling me giving birth in hospitals, vaccines, and working in air conditioned offices doesn’t extend life somewhat? People were also seeking powered flight for all of recorded history.

      • 4 hours

        Why is progress your target? Progress happens when ideas die.

    • How about not life extension but quality of life extension instead (e.g. this post)

      • 14 hours

        Indeed, I don’t really feel like living for more more than 90 years, I just want to be able to do what I like to do until I die.

    • 19 hours

      I didn’t realize people weren’t being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.

      • 18 hours

        LOL that pays for a focus group for branding. You can’t be serious.

        • 11 hours

          You’re telling me you’re a “huge nerd,” but think medical research is done by companies and involves focus groups? Like, it’s a Marvel or something?

          Jfc. If 90 million dollars isn’t anything to you, howbout you give yours away then bud.

          • 11 hours

            Yes, medicine is marketed. Are you for real? Like, is there still amniotic fluid behind your ears? Great Hatching Day fellow creature! Welcome to Earth!

            My joke was that tens of millions of dollars to research aging barely covers the test tubes. JFC.

            • 10 hours

              Bud, they don’t market for a treatment before there’s even research conducted. How the fuck are you acting like you think giant research grants are not effort? Give me ten million dollars if it isn’t much then.

              • 4 hours

                Sigh. What kind of absurd logic are you using? Do you not get sarcasm? I’m saying in the scheme of things, ten million dollars is nothing. The fact I don’t have ten millions dollars is irrelevant and your type of argument is at the level of an eight year old’s.

                We spend more than that developing idiotic video games that mean nothing.

                • 3 hours

                  “Le Sigh. You are but a juvenile child, and I the calm and logical adult. The arguments I make are simply too complex for such an underdeveloped mind; my explanations would only fall on deaf ears. Even the machinations of my coy wordplay is lost on you, clearly, for you could not even decipher the hidden meaning behind my deceptively foolish appraisal of this society’s motivations. My account is of the sheer scale of human productivity, a folley by which your feeble little brain could not even begin to comprehend.”

                  Dude, you’re cringe. People have literally been obsessed with medicalizing anti-aging since before the Renaissance. You think we’re only just now, in 2026, taking arthritis seriously? C’mon. You said something dumb and you’re too much of an internet trilby enthusiast to even take a second and consider what it means that thousands of people are applying for, acquiring, and expending massive amounts of grant funding toward this endeavour and have been doing so for decades.

                  Not gonna be engaging with this anymore, only made this comment because of how you characterized yourself in this response.

  • Americans, we get it, you have no healthcare system worth the name. Stop assuming nobody else worldwide can get the meds either.

    • 20 hours

      Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.

      The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn’t matter how much it costs.

    • 16 hours

      Or maybe you could show a little sympathy once in a while

      • America did this shit to itself

        And the civilised world gets dragged into the bullshit

        And before you whine, the majority of Americans are a part of the problem in one way or another

        Your society (for want of a better term) has gotten what it collectively wants

      • You try running into comments thinking they’re the only nation on earth in every health article and see how long you stay sympathetic.

    • 19 hours

      Sorry, is this not meant to sound like you’re a Eurocentrist douchebag? Medical care and resources are already not distributed proportionately throughout the world exactly because a small number of nations benefit from a brutally extractive colonial system that requires the dehumanization of other groups to exist.

      The US doesn’t have a fucking healthcare system because it is a settler-colonial, imperialist military power that holds up the capitalist system that Europeans are such proud benefactors of. They violently enforce a system that inflicts as much precarity and vulnerability as possible on its people because it depends on preventing as many unprivileged people as possible from gaining enough resources to muster an effective challenge to its power within the metropole while maintaining its legitimacy to its more privileged working classes.

      So, what the fuck are you bitching about? Americans saying that people won’t be able to afford it? They’re correct, most people will not have access to it so that fucks like you can thanks to the US guarding the loot. Fuck’s sake with you people.

      Edit: Before any Euros try to bitch and whine about how unfair it is that you’re still colonizers, I do not care. I don’t fucking care. We are not going to do this thing where you can bitch about the US and pretend like you aren’t world destroyers for the same exact fucking reason it is. If you are not critical of how many EU and European settler nations have the wealth to sustain a healthcare system and quality of life that makes access to medicine an entitlement instead of a privilege, you’re not a serious person.

      • I’m Asian. My country was colonised by Europeans till half a century ago.

        Keep going, this is funny. We’ve gone from ‘America is the only nation on earth’ to ‘oh yeah, Europe exists too’.

        • 13 hours

          I’m Eastern European, my country was exploited by USSR until less than 40 years ago. My bad for getting excited about the prospect of being able to walk in old age, it’s all my fault for -checks notes- joining a freedom of trade and movement organisation

          • 12 hours

            my country was exploited by USSR

            Do you have a source for that? The inefficiencies of Communism and the lack of cheap third world resources is not the same as being colonised or post-colonised like a third world country.

        • 14 hours

          Maybe orioler25 will figure out that there’s more to the world than only the US and EU :D

          • 11 hours

            Reread the comment and tell yourself that a criticism of EuroAmerican global imperialism is without consideration of colonized peoples. This history happened, sorry it compromises whatever power fantasy you have.

      • Australian here

        Fuck off with your whining

        You idiots did this to yourselves, ironically as a collective, because of your worship of the individual over society

        Suck it, yank.

        • Says the guy that just let the trojan horse of age controls behind the walls of their liberal democracy. Get off your high horse mate, it’s time for your colonoscopy to prove you can use the internet so they can craft your social score off of all your information on half baked palantir ai models. Oi oi oi!

        • 12 hours

          Not USAmerican. I’m willing to bet your colonizing ass doesn’t even know about Australia, look up Patrick Wolfe.

      • 17 hours

        Waaah they called out my US defaultist ass and now I need to crash out that the Euros built functioning societies waaaaaaaah

        • 11 hours

          Hey, how’d they build those “functioning” societies? Got a source? Extra points if you can even cite a decolonial history written by an indigenous person.

          Nice little extra ableism in your comment too, like a good colonizer chud would say.

          • 11 hours

            Reeeee anything I don’t like is brutal colonialism! Those damn Irish colonising Ireland! Don’t get me started on the fucking Icelanders! Reeeeeee

            • 11 hours

              You’re saying you think it makes you sound smart to suspend your object permanence. Guess a capitalist system with so much wealth concentrated in the EU just happened, it’s just like that. If you want to be in the Colonial League of Doom, every single individual in your country must personally be a rubber baron. Otherwise, you’re valour stealing bastards, actually free from colonialism completely, and a hysterical blue haired SJW.

              I seriously don’t know how you could type this shit and still respect yourself.

    • 1 day

      If you think anyone but the elite will be able to afford or procure these procedures, you’re incredibly optimistic.

      As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.

        • 1 day

          Bremonia will have the procedures, for free. The name can be changed, I don’t care. I just need help overthrowing a few corrupt governments and I’m out.

      • 23 hours

        This drug can be delivered via pill. It has a range of effects in reversing age related damage.

        I’m not sure if it will be kept to the rich, or given out widely to justify the removal of social security, or at least jacking up the retirement age.

        • 50 minutes

          They openly want to reduce the population in the US by over 100 million. It will absolutely be kept to the right kinds of people, which are the wrong kinds of people.

        • Maybe, but if PGE2 signaling is disrupted in non-cartilage tissues, it could promote abnormal growth or inflammation. For example, PGE2 has complex roles in cancer and fibrosis. And if the drug isn’t perfectly specific, it might inhibit other enzymes or pathways. This is because 15-PGDH is active in other tissues (e.g., liver, muscle, bone). Inhibiting it systemically might affect these tissues, though the study suggests localized joint injection could minimize this I suppose…

        • 22 hours

          If the worker-slaves live longer, you don’t have to indoctrinate & capture new ones quite as often!

          • I’d like my partners knees to work again so they can do the things they like as they age, like riding bikes or hiking.

            • I’d like my partner’s knees to work again so they can do something I like. On their knees. To me.

              There’s also some riding somewhere in there I suppose.

            • 19 hours

              Are you seriously also down here saying racist shit to a Native American so that you can roleplay some flex on what you thought was just some poor USAmerican who couldn’t afford healthcare? Your good guy scenario was dunking on a poor person in an authoritarian state?

              Europeans are seriously the most bloodthirsty fucks I’ll see online, and they’re predictably the most smug about it too.

              • I have no idea what you’re trying to say. Are you saying he’s NOT an American because he’s indigenous? And wtf is racist? At least now I know what his comment means. You people think everybody knows the same things you do.

                (I’m Asian BTW, but yeah go on)

                • 11 hours

                  Oh but how dare you be Asian when you were already assigned European at post /s

                • 11 hours

                  “It isn’t racist to call a Native American a ‘yank’ because I’m ignorant about racism.” You’re telling me that you moderate a Norwegian community, talk a shit ton about Euro nations, but you think it doesn’t make you look like a racist asshole to not know what is racist about trying to dunk on an indigenous person (who, again, you thought was just some other poor person) by calling them a term that identifies them with the occupying settler state that has committed genocide against their people.

                  Yeah dude, totally not a bloodthirsty chud.

              • What do Europeans have to do with this?
                Oh right, US-ians think any first-world country must be in Europe…

  • 15 hours

    This would be amazing for my wife. I mean I guess it would have been amazing if she still had her original knee. Maybe it’ll be amazing for the other knee one day.

  • Ready for someone to tell me why this unfortunately won’t work / become mainstream

    • 23 hours

      Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.

      Because PDGH-15 also causes age related muscle weakness.

      Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.

      I don’t know if the results of the phase 1 trials have been published yet, but it’s been a while since I checked.

      I’ve been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.

  • 19 hours

    I remember when I was a senior in high school back in the late 90s, my biology teacher mused one day that ours might be the first generation to not die of old age. I don’t know if I’m anywhere near as optimistic now as he was then, but it is incredibly exciting to think about. There have been a slew of discoveries over the past 20 years that have been building towards this, and it’s all been very fascinating. No idea if this is the grail or not, but it certainly seems like an important piece of the puzzle.

    • 15 hours

      my biology teacher mused one day that ours might be the first generation to not die of old age.

      Good for you that it was not the history teacher.

    • not dying of old age is a stretch. probably not dying young of certain diseases has improved.