Stanford scientists regrow lost cartilage and reverse arthritis in major breakthrough

Just take some from someone. Jeez, the learned helplessness of some people…

“but does it cause cancer” is the new “but so does a handgun” comic.

I would trade cancer down the road for my joints working now :(

That’s a Future You problem. You want this or not?

in fact, we’re in the early days of human gene technology, hormone therapy, biochemistry tempering etc.

Now we only need a drug to turn humans into mice and back.

Mice are really living in a golden age. They have never been so healthy.

And human tissues, and it’s been shown to be safe in phase I trials.

So saying “in mice” undersells where they are at.

They started with mice. As does all experiments.

Did you only read half way through before reaction posting?

Weird.

https://xkcd.com/1217/

Take a drug to regrow cartilage and get w vaccine for the cancer it allows.

With enough science, anything is possible.

Hopefully not just humans. Many dogs for example suffer from the very same issues when they get older.

… potentially prevent chronic pain and mobility issues in millions of tens of ultrarich people.

FTFY

Only the rich will benefit.

Is it though? The only time progress happens is when people die.

Its mostly billionaires who will be able to benefit from life extension… do you really want a world where trump, musk, and all their silicon valley friends rule the world until they turn 300 years old?

People have been seeking life extension for all of recorded history.

How about not life extension but quality of life extension instead (e.g. this post)

I didn’t realize people weren’t being serious about it this whole time. The tens of millions of dollars of research grants seemed pretty serious.

She’s still got hips and shoulders too I hope.

It inhibits the development of osteoarthritis following knee replacement too, so it might benefit both.

Exactly. Functional public health systems will assess patient outcomes and the expenditure in money and resources to determine what treatments get approved.

The odds are pretty good that - if this works out - this will be on the list of approved treatments straight away. Surgery is an expensive and high-load pathway for public health systems. A non-surgical treatment that gives good outcomes is such a win-win for both patients and public health systems that it almost doesn’t matter how much it costs.

Or maybe you could show a little sympathy once in a while

Sorry, is this not meant to sound like you’re a Eurocentrist douchebag? Medical care and resources are already not distributed proportionately throughout the world exactly because a small number of nations benefit from a brutally extractive colonial system that requires the dehumanization of other groups to exist.

The US doesn’t have a fucking healthcare system because it is a settler-colonial, imperialist military power that holds up the capitalist system that Europeans are such proud benefactors of. They violently enforce a system that inflicts as much precarity and vulnerability as possible on its people because it depends on preventing as many unprivileged people as possible from gaining enough resources to muster an effective challenge to its power within the metropole while maintaining its legitimacy to its more privileged working classes.

So, what the fuck are you bitching about? Americans saying that people won’t be able to afford it? They’re correct, most people will not have access to it so that fucks like you can thanks to the US guarding the loot. Fuck’s sake with you people.

Edit: Before any Euros try to bitch and whine about how unfair it is that you’re still colonizers, I do not care. I don’t fucking care. We are not going to do this thing where you can bitch about the US and pretend like you aren’t world destroyers for the same exact fucking reason it is. If you are not critical of how many EU and European settler nations have the wealth to sustain a healthcare system and quality of life that makes access to medicine an entitlement instead of a privilege, you’re not a serious person.

If you think anyone but the elite will be able to afford or procure these procedures, you’re incredibly optimistic.

As soon as it gets approved, some shitty corporation will purchase the patent and lock it behind a paywall for 80+ year old geriatrics with zero fucks given towards people who actually deserve or need it.

Well, this same drug (working name MF-300) is a PDGH-15 inhibitor and has already been through phase 1 human trials for a separate condition.

Because PDGH-15 also causes age related muscle weakness.

Now, PDGH-15 also plays a role in cancer prevention, and there may be a few other less obvious functions.

I don’t know if the results of the phase 1 trials have been published yet, but it’s been a while since I checked.

I’ve been hearing about MF-300 for a little under a year, and with these same claims about restoring cartilage.

Money, usually. Or cancer. God i sound depressing 😄

my biology teacher mused one day that ours might be the first generation to not die of old age.

Good for you that it was not the history teacher.

What exactly is exciting about making genocidal maniacs practically immortal?

not dying of old age is a stretch. probably not dying young of certain diseases has improved.

Yeah but while PGE2 promotes cartilage repair, it also plays roles in inflammation, fever, and gastrointestinal issues. If PGE2 levels rise too high or in the wrong context, it could cause unwanted inflammation or side effects similar to NSAIDs (e.g. stomach irritation).

in mice though, since none of these recent one works in humans yet.